"Here we propose a series of measures that we believe will improve research efficiency and robustness of scientific findings by directly targeting specific threats to reproducible science. We argue for the adoption, evaluation and ongoing improvement of these measures to optimize the pace and efficiency of knowledge accumulation. The measures are organized into the following categories methods, reporting and dissemination, reproducibility, evaluation and incentives. They are not intended to be exhaustive, but provide a broad, practical and evidence-based set of actions that can be implemented by researchers, institutions, journals and funders."